django expert configure server for subdomain

i need to fix the configuration of a virtual server that is working with Django [linux], I have 2 websites, one main website on Django and a second website on Django that is a subDomain of the first domain, I have a problem of intermittent 500 page, internal server error, when entering the subdomain [some times connect fine, some times 500] also to fix a configuration for the domain and server being problematic and to set a google mail account with the domain MX.