Require Instructions on Proper Graphic Knockouts For Final Print To Publisher

I am looking for a person who has first hand experience in preparing graphics for printing to a print shop, for an example to Uprinting.dot_com I am needing instructions on how to structure the text and graphics to obtain the knock-out technique on the artwork. The item being printed on is a recycled cardboard stock, where some of the text and graphics will show through, meaning that those areas will not have ink placed. I have done this type of work for a long time in both Illustrator and Photoshop using layers, but that is for web, not for final print, which is different. I have included a sample image which reflects exactly what I wish to achieve in my final artwork. Your instructions need to be clear enough that allows be to understand how to achieve the desired results as requested. I am sure that with someone with the know-how, I would be off and going in about 10 minutes or less. Thank You